Journal: Molecular Metabolism
Article Title: Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training
doi: 10.1016/j.molmet.2024.101980
Figure Lengend Snippet: Loss of skeletal muscle BMAL1 causes rewiring of inflammatory and metabolic pathways across multiple tissues after exercise training. Deseq2 normalized counts were used to produce within tissue Z-scores for all expressed genes for all 4 experimental groups. Average Z-scores were then produced from all genes found within the given KEGG pathway for vehicle exercise trained (gray bars) and iMSBmal1KO exercise trained mice (dark blue bars) for each tissue. Tissues are indicated by green bars (Gastrocnemius Muscle), light blue bars (iWAT), yellow bars (Liver), red bars (Heart) and purple bars (Lung). Data is presented for KEGG pathways related to (A) the Immune System, (B) Endocrine System and (C) Amino Acid, Carbohydrate and Lipid Metabolism. Blue signifies relative upregulation of associated pathways and red signifies relative downregulation of the genes within the associated pathways.
Article Snippet: Differentially expressed genes (DEGs) were identified through the Partek® Flow® DESeq2 binomial generalized linear model with Wald testing for significance between conditions.
Techniques: Produced